England: 15 Elliot Daly, 14 Anthony Watson, 13 Henry Slade, 12 Owen Farrell (c), 11 Jonny May, 10 George Ford, 9 Ben Youngs, 8 Billy Vunipola, 7 Tom Curry, 6 Courtney Lawes, 5 Jonny Hill, 4 Maro Itoje, 3 Kyle Sinckler, 2 Luke Cowan-Dickie, 1 Mako Vunipola
Replacements: 16 Jamie George, 17 Ellis Genge, 18 Will Stuart, 19 Charlie Ewels, 20 Ben Earl, 21 Jack Willis, 22 Dan Robson, 23 Max Malins
Italy: 15 Jacopo Trulla, 14 Luca Sperandio, 13 Juan Ignacio Brex, 12 Carlo Canna, 11 Montanna Ioane, 10 Paolo Garbisi, 9 Stephen Varney, 8 Michele Lamaro, 7 Johan Meyer, 6 Sebastian Negri, 5 David Sisi, 4 Marco Lazzaroni, 3 Marco Riccioni, 2 Luca Bigi, 1 Andrea Lovotti
Replacements: 16 Gianmarco Lucchesi, 17 Danilo Fischetti, 18 Giosuè Zilocchi, 19 Niccolò Cannone, 20 Federico Ruzza, 21 Guglielmo Palazzani, 22 Tommaso Allan, 23 Federico Mori
Date: Saturday, February 13
Venue: Twickenham
Kick-off: 14:15 GMT
Referee: Mike Adamson (Scotland)
Assistant Referees: Romain Poite (France), Ben Blain (Scotland)
TMO: Joy Neville (Ireland)